2-hydroxyglutaric aciduria D-2-hydroxyglutaric aciduria OMIM:PS600721 DOID:0050575 GARD:5661 disease_ontology An 2-hydroxyglutaric aciduria that involves developmental delay, seizures, weak muscle tone (hypotonia), and abnormalities in the largest part of the brain (the cerebrum), which controls many important functions such as muscle movement, speech, vision, thinking, emotion, and memory.