anencephaly DOID:0060668 A congenital nervous system abnormality characterized by failure of the anterior neuropore to close resulting in partial or complete absence of the cranial vault accompanied by absence of overlying tissues, including the brain and cerebral hemispheres, skull and scalp. ORDO:1048 MESH:D000757 OMIM:206500 disease_ontology ICD10CM:Q00.0 GARD:5808 congenital nervous system abnormality