hyper IgM syndrome NCI:C3990 disease_ontology DOID:0080544 OMIM:PS308230 A hyperimmunoglobin syndrome that is characterized by an immune system that fails to produce normal levels of the antibodies IgA, IgG and IgE but can produce normal or elevated levels of IgM. immunodeficiency with hyper-IgM hyperimmunoglobulin syndrome