angle-closure glaucoma primary angle-closure glaucoma An angle-closure glaucoma characterized by closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Primary angle-closure glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Primary angle closure glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component. DOID:1405 UMLS_CUI:C0017606 ICD9CM:365.2 ICD10CM:H40.2 disease_ontology SNOMEDCT_US_2020_03_01:193544008 primary Angle Closure Glaucoma