Leigh disease NCI:C84814 MESH:D007888 GARD:6877 ORDO:506 ICD10CM:G31.82 DOID:3652 UMLS_CUI:C0023264 OMIM:256000 SNOMEDCT_US_2020_03_01:29570005 disease_ontology Xref MGI. OMIM mapping confirmed by DO. [SN]. A mitochondrial metabolism disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity. Infantile necrotizing encephalomyelopathy Leigh syndrome juvenile subacute necrotizing encephalomyelopathy subacute necrotizing encephalomyelopathy mitochondrial metabolism disease