MELAS syndrome SNOMEDCT_US_2020_03_01:39925003 DOID:3687 MESH:D017241 MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKE-LIKE EPISODES disease_ontology ICD10CM:E88.41 NCI:C84885 A mitochondrial encephalomyopathy that is characterized by mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, has_symptom myalgia, motor weakness, headaches, seizures, and stroke-like episodes with acute hemiparesis and severe headaches, and develops_from mutation in mitochondrial genes including MT-TL1, which encodes tRNA proteins. OMIM mapping confirmed by DO. [SN]. UMLS_CUI:C0162671 OMIM:540000 mitochondrial encephalomyopathy