autosomal recessive disease syndrome Werner syndrome disease_ontology NCI:C3447 A syndrome characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers and that has_material_basis_in mutations in the WRN gene, on chromosome 8. OMIM mapping confirmed by DO. [LS]. DOID:5688 GARD:7885 UMLS_CUI:C0043119 SNOMEDCT_US_2020_03_01:51626007 MESH:D014898 ORDO:902 OMIM:277700 WS Werner's syndrome adult premature ageing syndrome adult progeria