hypersensitivity reaction type IV disease autoimmune lymphoproliferative syndrome UMLS_CUI:C1328840 ORDO:3261 MESH:D056735 Xref MGI. OMIM mapping confirmed by DO. [SN]. disease_ontology NCI:C37864 GARD:8686 OMIM:601859 DOID:6688 ICD9CM:279.41 A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen. ALPS SNOMEDCT_US_2020_03_01:702444009 MESH:D056735 ICD10CM:D89.82 Canale-Smith syndrome