multiple carboxylase deficiency holocarboxylase synthetase deficiency MESH:D028922 GARD:2721 SNOMEDCT_US_2020_03_01:15307001 ICD10CM:D81.818 A multiple carboxylase deficiency that involves a deficiency in holocarboxylase synthetase. disease_ontology Multiple carboxylase deficiency - neonatal onset UMLS_CUI:C0268581 OMIM:253270 DOID:859 OMIM mapping confirmed by DO. [SN]. NCI:C98842 Biotin-(propionyl-CoA-carboxylase) ligase deficiency