microsomal stability assay liver microsome stability PubChem AID: 504610 microsome stability assay metabolic stability in liver microsomes A common in vitro ADME assay that tests the stability of compounds when incubated with liver microsomes (subcellular fractions which contain membrane-bound drug-metabolizing enzymes). Assay is used to measure in vitro intrinsic clearance or to identify metabolites formed. Typically liver microsomes from one or more mammalian species (mouse, rat, dog, monkey, human) are analyzed to understand differences in metabolism. Can be reported as % recovery after a set time (single timepoint), or as half-life (multiple timepoints). Date from BAE: 6/6/2016 microsomal stability liver microsomal stability microsome stability metabolic stability assay