mouse strain Ptf1a{tm1Mgn} mouse strain Person: Mark A. Magnuson, Jill Lindner, Jean-Philippe Cartailler Ptf1a{tm1Mgn} RES236 mouse strain A mouse strain in which part or all of the targeted gene, pancreas specific transcription factor, 1a (NCBI Gene ID: 19213) is replaced to create ptf1a{tm1.1(YFP)} using the Loxed Cassette Acceptor allele Ptf1a{tm1(LCA)}). <p>Ptf1a{YFP} mice may be used to visualize yellow fluorescent protein (YFP) expression from the ptf1a allele. Ptf1a is expressedin pancreatic buds beginning at E9.5 andplays a vital role in the growth and lineage specification of pancreatic multipotent progenitor cells (MPCs). Ptf1a is also expressed in the neuronal precursors of the cerebellum, spinal cord, and retina where it also performs fate determining roles.</p> STOCK Ptf1atm1.1Mgn/Mmmh mouse strain Vanderbilt University Medical Center ptf1aYFP mouse strain