has part realizes has_specified_output achieves_planned_objective has participant role of deoxyribonucleic acid evaluant role DNA sequencing library preparation cross linking DNA sequence data multiplex ligation-mediated amplification chromosome conformation identification objective Carbon-copy chromosome conformation capture assay ENCODE project Venkat Malladi, Chris Stoeckert, Jie Zheng "Dostie et al. Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. Genome Res. 2006 October; 16(10):1299-309.[PMID:16954542]" An assay that is used to analyze the organization of chromosomes at the genome-wide scale. van Berkum et al. Determining spatial chromatin organization of large genomic regions using 5C technology. Methods Mol Biol (2009) vol. 567 pp. 189-213 [PMID:19588094] 5C 5C assay Carbon-copy chromosome conformation capture assay DNA sequencer sequencing assay specific enzymatic cleavage metadata complete