achieves_planned_objective
total intensity transformation single
Philippe Rocca-Serra
A total intensity transformation single is a data transformation that takes as input an n-dimensional (real) vector and multiplies each component of this vector by a coefficient, where the coefficient is obtained by taking the sum of the input components or of a subset of these, multiplied by a constant of choice.
Elisabetta Manduchi
Helen Parkinson
James Malone
Melanie Courtot
Note that if the word "sum" is replaced by the word "mean" in the definition, the resulting definition is equivalent.
OTHER: Adjusted from MGED Ontology
This can be used as a simple normalization method for expression microarray assays. For example, each intensity from a one-channel microarray assay is multiplied by a constant so that the output mean intensity over the microarray equals a desired target T (the multiplicative constant in this case is the T/(mean intensity)).
total intensity transformation single
data normalization objective
normalization data transformation
ready for release