role EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme. yes PMID:20467214 HMG-CoA reductase inhibitor CHEBI:35664 chebi_ontology PMID:15531285 hydroxymethylglutaryl-CoA reductase inhibitor HMG-CoA reductase inhibitors Wikipedia:HMG-CoA_reductase hydroxymethylglutaryl-CoA reductase inhibitors PMID:1464741