isBiomarkerOfAging disease hayflick limit The Hayflick limit refers to the discovery by Leonard Hayflick that normal human cells grown in culture can only divide a finite number of times before entering a state of senescence, where they cease to divide. It describes a limit on the process of cell division and is related to the concept of cellular senescence. https://pubmed.ncbi.nlm.nih.gov/11413492/ biological principle