isBiomarkerOfAging metric disease extrinsic epigenetic age acceleration generated with ChatGPT-4 on 09․10․24 EEAA Extrinsic Epigenetic Age Acceleration is a metric used to estimate biological aging by incorporating both DNA methylation patterns and changes in blood cell composition. This measure reflects the combined effects of intrinsic cellular aging (similar to IEAA) and the aging of the immune system, which involves shifts in certain immune cell types, such as T cells and B cells.