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    <!-- http://purl.obolibrary.org/obo/DOID_0014667 -->

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        <rdfs:label>disease of metabolism</rdfs:label>
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        <rdfs:label>calcium metabolic disease</rdfs:label>
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        <oboInOwl:hasDbXref>ICD9CM:275.4</oboInOwl:hasDbXref>
        <ns3:IAO_0000115>Disorders of calcium metabolism occur when the body has too little or too much calcium. The serum level of calcium is closely regulated within a fairly limited range in the human body. In a healthy physiology, extracellular calcium levels are maintained within a tight range through the actions of parathyroid hormone, vitamin D and the calcium sensing receptor.[1] Disorders in calcium metabolism can lead to hypocalcemia, decreased plasma levels of calcium or hypercalcemia, elevated plasma calcium levels.</ns3:IAO_0000115>
        <oboInOwl:hasExactSynonym>calcium metabolic disorder</oboInOwl:hasExactSynonym>
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        <oboInOwl:hasExactSynonym>calcium metabolism disorder</oboInOwl:hasExactSynonym>
        <rdfs:comment>Defined in terms of GO calcium ion homeostatis. Also consistent with HPO. Note advice from GO as calcium ions are neither created or destroyed is not metabolic process in terms of go, but name retained for purposes of consistency with e.g. Snomed and Mesh, Consider relocating this as a sibling of metabolic disease.</rdfs:comment>
        <oboInOwl:hasDbXref>MONDO:0005557</oboInOwl:hasDbXref>
        <ns2:definition_citation>DOID:10575</ns2:definition_citation>
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        <oboInOwl:hasDbXref>ICD9:275.49</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>SCTID:71638002</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>calcium metabolism disease</oboInOwl:hasExactSynonym>
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        <oboInOwl:hasDbXref>SNOMEDCT:190863003</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>Calcium Metabolism Disorders</oboInOwl:hasExactSynonym>
        <ns3:IAO_0000117>Helen Parkinson</ns3:IAO_0000117>
        <oboInOwl:hasDbXref>UMLS:C0006705</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>calcium metabolic disease</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>ICD9CM:275.40</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ICD9:275.40</oboInOwl:hasDbXref>
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        <oboInOwl:hasExactSynonym>disorder of calcium metabolism</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>SNOMEDCT:71638002</oboInOwl:hasDbXref>
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        <ns3:IAO_0000115>Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.</ns3:IAO_0000115>
        <oboInOwl:hasDbXref>DOID:10575</oboInOwl:hasDbXref>
        <rdfs:comment>Defined in terms of GO calcium ion homeostatis. Also consistent with HPO. Note advice from GO as calcium ions are neither created or destroyed is not metabolic process in terms of go, but name retained for purposes of consistency with e.g. Snomed and Mesh</rdfs:comment>
        <rdfs:comment>Consider relocating this as a sibling of metabolic disease. </rdfs:comment>
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