derives from/develops from macrophage foreign-body giant cell BTO:0003107 BrendaTissueOBO Syncytium formed by the fusion of macrophages in response to an indigestible particle too large to be phagocytosed for example talc, silica or asbestos fibres. Multinucleated cells (fused macrophages), characteristic of granulomatous inflammation, which form around exogenous material in the skin. They are similar in appearance to Langhans giant cells, but foreign-body giant cells have more abundant chromatin and their nuclei are scattered in an irregular pattern in the cytoplasm. foreign body giant cell