derives from/develops from synovial tissue rheumatoid arthritis disease specific synovial tissue BTO:0003702 BrendaTissueOBO Chronic inflammatory disease in which there is destruction of joints. Considered by some to be an autoimmune disorder in which immune complexes are formed in joints and excite an inflammatory response (complex mediated hypersensitivity). Cell-mediated (type IV) hypersensitivity also occurs and macrophages accumulate. This in turn leads to the destruction of the synovial lining. rheumatoid arthritis synovial tissue