disease causes dysfunction of cerebral white matter leukodystrophy disease specific cell type 2016-04-18T09:29:37Z BTO:0005830 BrendaTissueOBO Leukodystrophy is a term for a group of white matter diseases, some familial, characterized by progressive cerebral deterioration usually in early life, and pathologically by primary absence or degeneration of the myelin of the central and peripheral nervous systems with glial reaction; probably related to a defect in lipid metabolism. Marion, contact@brenda-enzymes.org