human_reference_atlas cell cell type (from CL) mature neutrophil mature neutrocyte mature neutrophilic leukocyte neutrophil (normally intravascular only) CT polymorphonuclear leukocyte neutrophil (normally intravascular only) polymorphonuclear leucocyte mature neutrophil leukocyte poly mature neutrophilic leucocyte mature neutrophil leucocyte BTO:0003473 polynuclear neutrophilic leukocyte polymorphonuclear neutrophil A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive. Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)). PMN CL:0000096 polynuclear neutrophilic leucocyte neutrophil immature neutrophil Homo sapiens large intestine anal canal cecum mucosa colonic mucosa ileocecal valve rectum caecum vermiform appendix ascending colon transverse colon descending colon sigmoid colon gut-associated lymphoid tissue mucosa of anal canal mucosa of appendix splenic flexure of colon hepatic flexure of colon