human_reference_atlas has characterizing marker set has marker component SLC16A1 TNFSF10 TPSAB1 TPSB2 CCR3 HPGDS CLC HECA CPA3 PLIN2 ENPP3 FCER1A GATA2 HDC IL1RL1 IL5RA IL7R KIT LMO4 MS4A2 MS4A3 cell cell type (from CL) granulocyte mast cell CL:0000097 mast cell labrocyte tissue basophil CT Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. mast cell FMA:66784 A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development. BTO:0000830 mast cells Mast cell Mast Cell histaminocyte mast cells mastocyte CALOHA:TS-0603 secretory cell myeloid leukocyte Homo sapiens sequence collection lymph node large intestine anal canal cecum mucosa colonic mucosa duodenal mucosa jejunal mucosa ileocecal valve heart rectum caecum vermiform appendix ascending colon transverse colon descending colon sigmoid colon anus mucosa-associated lymphoid tissue gut-associated lymphoid tissue cortex of lymph node medulla of lymph node dermis hypodermis right cardiac atrium left cardiac atrium heart right ventricle heart left ventricle interventricular septum skin of body small intestine kidney duodenum jejunum capsule of thymus subcutaneous adipose tissue epicardium thymus bone marrow mucosa of anal canal cardiac muscle tissue of interventricular septum fallopian tube uterine tube infundibulum thymus trabecula mucosa of appendix kidney interstitium left ventricle myocardium right ventricle myocardium lymph node medullary cord ampulla of uterine tube duodenum lamina propria isthmus of fallopian tube splenic flexure of colon hepatic flexure of colon fimbria of uterine tube lymph node paracortex lymph node paracortical cord Distal part of ileum Duodenum Myocardium of interventricular septum intramural segment of fallopian tube lamina propria fallopian tube ampulla lamina propria/gut associated lymphoid tissue (galt) lamina propria of fallopian tube fimbria lamina propria of fallopian tube infundibulum lamina propria of fallopian tube intramural segment lamina propria of fallopian tube isthmus mucosa