<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/CCFO-Slim?iri=http://purl.obolibrary.org/obo/CL_0000165"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
     xmlns:ns5="http://purl.org/ccf/"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:skos="http://www.w3.org/2004/02/skos/core#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_pref_label"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas">
        <rdfs:label>human_reference_atlas</rdfs:label>
    </AnnotationProperty>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_located_in"/>
    <AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#prefLabel"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_ct_isa"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_asctb_type"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002175"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0015004 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0015004">
        <rdfs:label>has characterizing marker set</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.org/ccf/has_marker_component -->

    <ObjectProperty rdf:about="http://purl.org/ccf/has_marker_component">
        <rdfs:label>has marker component</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://identifiers.org/hgnc/11506 -->

    <Class rdf:about="http://identifiers.org/hgnc/11506">
        <rdfs:label>SYP</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/1929 -->

    <Class rdf:about="http://identifiers.org/hgnc/1929">
        <rdfs:label>CHGA</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/6088 -->

    <Class rdf:about="http://identifiers.org/hgnc/6088">
        <rdfs:label>INSL5</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/6090 -->

    <Class rdf:about="http://identifiers.org/hgnc/6090">
        <rdfs:label>INSM1</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000000 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000000">
        <rdfs:label>cell</rdfs:label>
        <rdfs:label xml:lang="en">cell type (from CL)</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000165 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000165">
        <rdfs:label>neuroendocrine cell</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000540"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000710"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0015004"/>
                <someValuesFrom>
                    <Class>
                        <intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/SO_0001260"/>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/11506"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/1929"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/6088"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/6090"/>
                            </Restriction>
                        </intersectionOf>
                    </Class>
                </someValuesFrom>
            </Restriction>
        </rdfs:subClassOf>
        <ns5:ccf_pref_label>neuroendocrine cell</ns5:ccf_pref_label>
        <oboInOwl:hasRelatedSynonym>neurosecretory neuron</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>BTO:0002691</oboInOwl:hasDbXref>
        <skos:prefLabel>neuroendocrine</skos:prefLabel>
        <oboInOwl:hasDbXref>FBbt:00005130</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:83810</oboInOwl:hasDbXref>
        <skos:prefLabel>neuroendocrine cell</skos:prefLabel>
        <rdfs:comment>The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. 

The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron.</rdfs:comment>
        <ns5:ccf_asctb_type>CT</ns5:ccf_asctb_type>
        <ns4:IAO_0000115>A neuron that is capable of some hormone secretion in response to neuronal signals.</ns4:IAO_0000115>
        <oboInOwl:hasRelatedSynonym>neurosecretory cell</oboInOwl:hasRelatedSynonym>
        <ns5:ccf_pref_label>neuroendocrine</ns5:ccf_pref_label>
        <oboInOwl:id>CL:0000165</oboInOwl:id>
        <ns5:ccf_ct_isa rdf:resource="http://purl.obolibrary.org/obo/CL_0000000"/>
        <ns4:RO_0002175 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000059"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000159"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000314"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000317"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000569"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001052"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001153"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001154"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001156"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001157"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001158"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001159"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0003342"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0004989"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0007177"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0011184"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0011189"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0022276"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0022277"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0022281"/>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/cl.owl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000540 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000540">
        <rdfs:label>neuron</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000710 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000710">
        <rdfs:label>neurecto-epithelial cell</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_9606 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9606">
        <rdfs:label>Homo sapiens</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/SO_0001260 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/SO_0001260">
        <rdfs:label>sequence collection</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000059 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000059">
        <rdfs:label>large intestine</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000159 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000159">
        <rdfs:label>anal canal</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000314 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000314">
        <rdfs:label>cecum mucosa</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000317 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000317">
        <rdfs:label>colonic mucosa</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000569 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000569">
        <rdfs:label>ileocecal valve</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0001052 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001052">
        <rdfs:label>rectum</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0001153 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001153">
        <rdfs:label>caecum</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0001154 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001154">
        <rdfs:label>vermiform appendix</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0001156 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001156">
        <rdfs:label>ascending colon</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0001157 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001157">
        <rdfs:label>transverse colon</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0001158 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001158">
        <rdfs:label>descending colon</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0001159 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001159">
        <rdfs:label>sigmoid colon</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0003342 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0003342">
        <rdfs:label>mucosa of anal canal</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0004989 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0004989">
        <rdfs:label>mucosa of appendix</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0007177 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0007177">
        <rdfs:label>lamina propria of mucosa of colon</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0011184 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0011184">
        <rdfs:label>epithelium of crypt of Lieberkuhn</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0011189 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0011189">
        <rdfs:label>lamina propria of large intestine</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0022276 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0022276">
        <rdfs:label>splenic flexure of colon</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0022277 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0022277">
        <rdfs:label>hepatic flexure of colon</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0022281 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0022281">
        <rdfs:label>epithelium of crypt of Lieberkuhn of large intestine</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



