human_reference_atlas part of has characterizing marker set has marker component SLC18A2 TPSAB1 CMA1 CPA3 KIT MS4A2 PTPRC RGS13 cell cell type (from CL) mast cell connective tissue type mast cell TC mast cells MC(TC) MCTC Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent. They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. CT connective tissue type mast cell connective tissue type mast cell CL:0000484 Homo sapiens sequence collection respiratory tract respiratory system lower respiratory tract lung immune system