<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/CCFO-Slim?iri=http://purl.obolibrary.org/obo/CL_0000553"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
     xmlns:ns5="http://purl.org/ccf/"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:skos="http://www.w3.org/2004/02/skos/core#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_pref_label"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas">
        <rdfs:label>human_reference_atlas</rdfs:label>
    </AnnotationProperty>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_located_in"/>
    <AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#prefLabel"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_ct_isa"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_asctb_type"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002175"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0015004 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0015004">
        <rdfs:label>has characterizing marker set</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.org/ccf/has_marker_component -->

    <ObjectProperty rdf:about="http://purl.org/ccf/has_marker_component">
        <rdfs:label>has marker component</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://identifiers.org/hgnc/10690 -->

    <Class rdf:about="http://identifiers.org/hgnc/10690">
        <rdfs:label>CAVIN2</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/2067 -->

    <Class rdf:about="http://identifiers.org/hgnc/2067">
        <rdfs:label>PDLIM1</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/3609 -->

    <Class rdf:about="http://identifiers.org/hgnc/3609">
        <rdfs:label>FCER1A</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/3618 -->

    <Class rdf:about="http://identifiers.org/hgnc/3618">
        <rdfs:label>FCGR2B</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/4171 -->

    <Class rdf:about="http://identifiers.org/hgnc/4171">
        <rdfs:label>GATA2</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/4439 -->

    <Class rdf:about="http://identifiers.org/hgnc/4439">
        <rdfs:label>GP1BA</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/6138 -->

    <Class rdf:about="http://identifiers.org/hgnc/6138">
        <rdfs:label>ITGA2B</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/6156 -->

    <Class rdf:about="http://identifiers.org/hgnc/6156">
        <rdfs:label>ITGB3</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/8861 -->

    <Class rdf:about="http://identifiers.org/hgnc/8861">
        <rdfs:label>PF4</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/9070 -->

    <Class rdf:about="http://identifiers.org/hgnc/9070">
        <rdfs:label>PLEK</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000553 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000553">
        <rdfs:label>megakaryocyte progenitor cell</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000839"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0015004"/>
                <someValuesFrom>
                    <Class>
                        <intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/SO_0001260"/>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/10690"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/2067"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/3609"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/3618"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/4171"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/4439"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/6138"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/6156"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/8861"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/9070"/>
                            </Restriction>
                        </intersectionOf>
                    </Class>
                </someValuesFrom>
            </Restriction>
        </rdfs:subClassOf>
        <ns4:IAO_0000115>The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative).</ns4:IAO_0000115>
        <oboInOwl:hasDbXref>BTO:0001164</oboInOwl:hasDbXref>
        <ns5:ccf_pref_label>early megakaryocyte</ns5:ccf_pref_label>
        <oboInOwl:hasExactSynonym>megacaryocyte progenitor cell</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>megacaryoblast</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>MkP</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>colony-forming unit-megakaryocyte</oboInOwl:hasExactSynonym>
        <ns5:ccf_asctb_type>CT</ns5:ccf_asctb_type>
        <oboInOwl:hasDbXref>MESH:D055016</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>promegakaryocyte</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasExactSynonym>megakaryocytic progenitor cell</oboInOwl:hasExactSynonym>
        <oboInOwl:id>CL:0000553</oboInOwl:id>
        <skos:prefLabel>early Megakaryocyte</skos:prefLabel>
        <oboInOwl:hasExactSynonym>Meg-CFC</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>FMA:84235</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>CFU-Meg</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>megakaryoblast</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>CALOHA:TS-0610</oboInOwl:hasDbXref>
        <rdfs:comment>Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.</rdfs:comment>
        <oboInOwl:hasRelatedSynonym>promegacaryocyte</oboInOwl:hasRelatedSynonym>
        <ns5:ccf_ct_isa rdf:resource="http://purl.obolibrary.org/obo/CL_0000556"/>
        <ns4:RO_0002175 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002371"/>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/cl.owl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000556 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000556">
        <rdfs:label>megakaryocyte</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000839 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000839">
        <rdfs:label>myeloid lineage restricted progenitor cell</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_9606 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9606">
        <rdfs:label>Homo sapiens</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/SO_0001260 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/SO_0001260">
        <rdfs:label>sequence collection</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0002371 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0002371">
        <rdfs:label>bone marrow</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



