human_reference_atlas part of has characterizing marker set has marker component SDC1 SSR4 TNFRSF17 CD27 XBP1 DERL3 CD19 CD24 CD28 CD38 CD53 CD79A CKAP4 BANK1 FCRL5 FKBP11 CORO1A CR2 SEC11C CXCR4 MZB1 IGHA1 IGHD IGHG1 IGHG3 IGHM JCHAIN IGKC IRF4 ITGAL MS4A1 PECAM1 PRDM1 PTPRC cell cell type (from CL) plasma cell plasma cell Plasma Cell A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin. plasma cell MESH:D010950 plasma plasmocyte CT Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. CL:0000786 plasma BTO:0000392 plasmacyte plasma B cell plasma B-cell effector B-cell FMA:70574 effector B cell Plasma cell lymphocyte of B lineage Homo sapiens sequence collection lymph node large intestine respiratory tract anal canal cecum mucosa colonic mucosa duodenal mucosa jejunal mucosa ileocecal valve respiratory system rectum caecum vermiform appendix ascending colon transverse colon descending colon sigmoid colon red pulp of spleen marginal zone of spleen splenic cord lower respiratory tract gut-associated lymphoid tissue cortex of lymph node medulla of lymph node lung dermis skin of body spleen small intestine kidney duodenum jejunum thymus lobule thymus bone marrow palatine tonsil immune system mucosa of anal canal fallopian tube uterine tube infundibulum thymus corticomedullary boundary mucosa of appendix kidney interstitium thymus lobe lymph node medullary cord germinal center ampulla of uterine tube tonsil germinal center duodenum lamina propria isthmus of fallopian tube splenic flexure of colon hepatic flexure of colon spleen pulp fimbria of uterine tube lymph node paracortex lymph node paracortical cord Distal part of ileum Diffuse lymphoid tissue Duodenum intramural segment of fallopian tube lamina propria fallopian tube ampulla lamina propria/gut associated lymphoid tissue (galt) lamina propria of fallopian tube fimbria lamina propria of fallopian tube infundibulum lamina propria of fallopian tube intramural segment lamina propria of fallopian tube isthmus mucosa red pulp-white pulp border tonsil follicle tonsil secondary follicle