<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/CCFO-Slim?iri=http://purl.obolibrary.org/obo/CL_0000845"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
     xmlns:ns5="http://purl.org/ccf/"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:ccf="https://purl.org/ccf/"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:skos="http://www.w3.org/2004/02/skos/core#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_pref_label"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas">
        <rdfs:label>human_reference_atlas</rdfs:label>
    </AnnotationProperty>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_located_in"/>
    <AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#prefLabel"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_ct_isa"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_asctb_type"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002175"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/BFO_0000050 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000050">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:label xml:lang="en">part of</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0015004 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0015004">
        <rdfs:label>has characterizing marker set</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.org/ccf/has_marker_component -->

    <ObjectProperty rdf:about="http://purl.org/ccf/has_marker_component">
        <rdfs:label>has marker component</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://identifiers.org/hgnc/11922 -->

    <Class rdf:about="http://identifiers.org/hgnc/11922">
        <rdfs:label>CD27</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/1636 -->

    <Class rdf:about="http://identifiers.org/hgnc/1636">
        <rdfs:label>CD1C</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/1637 -->

    <Class rdf:about="http://identifiers.org/hgnc/1637">
        <rdfs:label>CD1D</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/2336 -->

    <Class rdf:about="http://identifiers.org/hgnc/2336">
        <rdfs:label>CR2</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/3612 -->

    <Class rdf:about="http://identifiers.org/hgnc/3612">
        <rdfs:label>FCER2</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/5480 -->

    <Class rdf:about="http://identifiers.org/hgnc/5480">
        <rdfs:label>IGHD</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/5541 -->

    <Class rdf:about="http://identifiers.org/hgnc/5541">
        <rdfs:label>IGHM</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/6018 -->

    <Class rdf:about="http://identifiers.org/hgnc/6018">
        <rdfs:label>IL6</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/7315 -->

    <Class rdf:about="http://identifiers.org/hgnc/7315">
        <rdfs:label>MS4A1</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000000 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000000">
        <rdfs:label>cell</rdfs:label>
        <rdfs:label xml:lang="en">cell type (from CL)</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000785 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000785">
        <rdfs:label>mature B cell</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000845 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000845">
        <rdfs:label>marginal zone B cell of spleen</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000785"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001251"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0015004"/>
                <someValuesFrom>
                    <Class>
                        <intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/SO_0001260"/>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/11922"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/1636"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/1637"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/2336"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/3612"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/5480"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/5541"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/6018"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/7315"/>
                            </Restriction>
                        </intersectionOf>
                    </Class>
                </someValuesFrom>
            </Restriction>
        </rdfs:subClassOf>
        <oboInOwl:hasBroadSynonym>MZ B lymphocyte</oboInOwl:hasBroadSynonym>
        <ns5:ccf_pref_label>superficial zone b cell</ns5:ccf_pref_label>
        <oboInOwl:hasBroadSynonym>marginal zone B cell</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasBroadSynonym>MZ B cell</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasBroadSynonym>marginal zone B-cell</oboInOwl:hasBroadSynonym>
        <oboInOwl:id>CL:0000845</oboInOwl:id>
        <oboInOwl:hasBroadSynonym>marginal zone B-lymphocyte</oboInOwl:hasBroadSynonym>
        <rdfs:comment>MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive.</rdfs:comment>
        <skos:prefLabel>Superficial Zone B Cell</skos:prefLabel>
        <ns5:ccf_asctb_type>CT</ns5:ccf_asctb_type>
        <oboInOwl:hasBroadSynonym>marginal zone B lymphocyte</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasExactSynonym>marginal zone of spleen B cell</oboInOwl:hasExactSynonym>
        <ns4:IAO_0000115>A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high.</ns4:IAO_0000115>
        <oboInOwl:hasExactSynonym>B cell of marginal zone of spleen</oboInOwl:hasExactSynonym>
        <oboInOwl:hasBroadSynonym>MZ B-cell</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasBroadSynonym>MZ B-lymphocyte</oboInOwl:hasBroadSynonym>
        <ns5:ccf_ct_isa rdf:resource="http://purl.obolibrary.org/obo/CL_0000000"/>
        <ns4:RO_0002175 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001251"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002106"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_1000023"/>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/cl.owl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas"/>
        <ns5:ccf_located_in rdf:resource="https://purl.org/ccf/ASCTB-TEMP_red-pulp-white-pulp-border"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_9606 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9606">
        <rdfs:label>Homo sapiens</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/SO_0001260 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/SO_0001260">
        <rdfs:label>sequence collection</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0001251 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001251">
        <rdfs:label>marginal zone of spleen</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0002106 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0002106">
        <rdfs:label>spleen</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_1000023 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_1000023">
        <rdfs:label>spleen pulp</rdfs:label>
    </Class>
    


    <!-- https://purl.org/ccf/ASCTB-TEMP_red-pulp-white-pulp-border -->

    <Class rdf:about="https://purl.org/ccf/ASCTB-TEMP_red-pulp-white-pulp-border">
        <rdfs:label>red pulp-white pulp border</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



