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     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
     xmlns:ns5="http://purl.org/ccf/"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:ccf="https://purl.org/ccf/"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:skos="http://www.w3.org/2004/02/skos/core#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
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    ///////////////////////////////////////////////////////////////////////////////////////
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    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_pref_label"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas">
        <rdfs:label>human_reference_atlas</rdfs:label>
    </AnnotationProperty>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_located_in"/>
    <AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#prefLabel"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_ct_isa"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_asctb_type"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002175"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
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    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0015004 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0015004">
        <rdfs:label>has characterizing marker set</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.org/ccf/has_marker_component -->

    <ObjectProperty rdf:about="http://purl.org/ccf/has_marker_component">
        <rdfs:label>has marker component</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://identifiers.org/hgnc/11922 -->

    <Class rdf:about="http://identifiers.org/hgnc/11922">
        <rdfs:label>CD27</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/1633 -->

    <Class rdf:about="http://identifiers.org/hgnc/1633">
        <rdfs:label>CD19</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/16837 -->

    <Class rdf:about="http://identifiers.org/hgnc/16837">
        <rdfs:label>LY86</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/18153 -->

    <Class rdf:about="http://identifiers.org/hgnc/18153">
        <rdfs:label>TNFRSF13B</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/18233 -->

    <Class rdf:about="http://identifiers.org/hgnc/18233">
        <rdfs:label>BANK1</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/206 -->

    <Class rdf:about="http://identifiers.org/hgnc/206">
        <rdfs:label>ADAM28</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/2360 -->

    <Class rdf:about="http://identifiers.org/hgnc/2360">
        <rdfs:label>CRIP1</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/3128 -->

    <Class rdf:about="http://identifiers.org/hgnc/3128">
        <rdfs:label>GPR183</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/4942 -->

    <Class rdf:about="http://identifiers.org/hgnc/4942">
        <rdfs:label>HLA-DQA1</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/4947 -->

    <Class rdf:about="http://identifiers.org/hgnc/4947">
        <rdfs:label>HLA-DRA</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/5478 -->

    <Class rdf:about="http://identifiers.org/hgnc/5478">
        <rdfs:label>IGHA1</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/7315 -->

    <Class rdf:about="http://identifiers.org/hgnc/7315">
        <rdfs:label>MS4A1</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000000 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000000">
        <rdfs:label>cell</rdfs:label>
        <rdfs:label xml:lang="en">cell type (from CL)</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000787 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000787">
        <rdfs:label>memory B cell</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000972 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000972">
        <rdfs:label>class switched memory B cell</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000787"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0015004"/>
                <someValuesFrom>
                    <Class>
                        <intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/SO_0001260"/>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/11922"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/1633"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/16837"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/18153"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/18233"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/206"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/2360"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/3128"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/4942"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/4947"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/5478"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/7315"/>
                            </Restriction>
                        </intersectionOf>
                    </Class>
                </someValuesFrom>
            </Restriction>
        </rdfs:subClassOf>
        <ns5:ccf_pref_label>memory b cell</ns5:ccf_pref_label>
        <skos:prefLabel>Switched B Cell</skos:prefLabel>
        <ns5:ccf_asctb_type>CT</ns5:ccf_asctb_type>
        <skos:prefLabel>memory B cell</skos:prefLabel>
        <oboInOwl:hasExactSynonym>class switched memory B-lymphocyte</oboInOwl:hasExactSynonym>
        <ns4:IAO_0000115>A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface.</ns4:IAO_0000115>
        <oboInOwl:hasExactSynonym>class switched memory B lymphocyte</oboInOwl:hasExactSynonym>
        <ns5:ccf_pref_label>switched b cell</ns5:ccf_pref_label>
        <oboInOwl:id>CL:0000972</oboInOwl:id>
        <rdfs:comment>Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive.</rdfs:comment>
        <oboInOwl:hasExactSynonym>class switched memory B-cell</oboInOwl:hasExactSynonym>
        <ns5:ccf_ct_isa rdf:resource="http://purl.obolibrary.org/obo/CL_0000000"/>
        <ns4:RO_0002175 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001250"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001251"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002106"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002125"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002370"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0003988"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0005483"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0010401"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0013132"/>
        <ns5:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_1000023"/>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/cl.owl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas"/>
        <ns5:ccf_located_in rdf:resource="https://purl.org/ccf/ASCTB-TEMP_red-pulp-white-pulp-border"/>
        <ns5:ccf_located_in rdf:resource="https://purl.org/ccf/ASCTB-TEMP_sheathed-capillary"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_9606 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9606">
        <rdfs:label>Homo sapiens</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/SO_0001260 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/SO_0001260">
        <rdfs:label>sequence collection</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0001250 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001250">
        <rdfs:label>red pulp of spleen</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0001251 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001251">
        <rdfs:label>marginal zone of spleen</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0002106 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0002106">
        <rdfs:label>spleen</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0002125 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0002125">
        <rdfs:label>thymus lobule</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0002370 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0002370">
        <rdfs:label>thymus</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0003988 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0003988">
        <rdfs:label>thymus corticomedullary boundary</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0005483 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0005483">
        <rdfs:label>thymus lobe</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0010401 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0010401">
        <rdfs:label>spleen central arteriole</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0013132 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0013132">
        <rdfs:label>penicillar arteriole</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_1000023 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_1000023">
        <rdfs:label>spleen pulp</rdfs:label>
    </Class>
    


    <!-- https://purl.org/ccf/ASCTB-TEMP_red-pulp-white-pulp-border -->

    <Class rdf:about="https://purl.org/ccf/ASCTB-TEMP_red-pulp-white-pulp-border">
        <rdfs:label>red pulp-white pulp border</rdfs:label>
    </Class>
    


    <!-- https://purl.org/ccf/ASCTB-TEMP_sheathed-capillary -->

    <Class rdf:about="https://purl.org/ccf/ASCTB-TEMP_sheathed-capillary">
        <rdfs:label>sheathed capillary</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



