human_reference_atlas part of has characterizing marker set has marker component SOX9 CD44 LRIG1 SMOC2 RGMB LGR5 cell cell type (from CL) intestinal epithelial cell intestinal crypt stem cell of large intestine epithelial stem cell CT epithelial stem cell crypt stem cell of large intestine An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells. stem cell of large intestine crypt of Lieberkuhn CL:0009016 Homo sapiens sequence collection large intestine anal canal cecum mucosa colonic mucosa ileocecal valve rectum caecum vermiform appendix ascending colon transverse colon descending colon sigmoid colon mucosa of anal canal mucosa of appendix epithelium of crypt of Lieberkuhn splenic flexure of colon hepatic flexure of colon epithelium of crypt of Lieberkuhn of large intestine