human_reference_atlas has characterizing marker set has marker component EPCAM CALCA CDH1 CDH18 CHGA ELF3 FXYD3 GRP ASCL1 NRXN1 cell cell type (from CL) neuroendocrine cell lung neuroendocrine cell pulmonary neuroendocrine cell PNEC CT A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury. lung neuroendocrine cell lung neuroendocrine cell CL:1000223 Homo sapiens sequence collection respiratory tract respiratory system lower respiratory tract epithelium of trachea segmental bronchus epithelium of segmental bronchus trachea tracheobronchial tree subsegmental bronchus bronchopulmonary segment