<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/CCFO-Slim?iri=http://purl.obolibrary.org/obo/CL_4030032"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:ns6="http://purl.org/ccf/"
     xmlns:ns5="http://purl.obolibrary.org/obo/"
     xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:dcterms="http://purl.org/dc/terms/"
     xmlns:skos="http://www.w3.org/2004/02/skos/core#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_pref_label"/>
    <AnnotationProperty rdf:about="http://purl.org/dc/terms/contributor"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas">
        <rdfs:label>human_reference_atlas</rdfs:label>
    </AnnotationProperty>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_located_in"/>
    <AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#prefLabel"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://purl.org/dc/terms/date"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_ct_isa"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.org/ccf/ccf_asctb_type"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002175"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/BFO_0000050 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000050">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:label xml:lang="en">part of</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0015004 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0015004">
        <rdfs:label>has characterizing marker set</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.org/ccf/has_marker_component -->

    <ObjectProperty rdf:about="http://purl.org/ccf/has_marker_component">
        <rdfs:label>has marker component</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://identifiers.org/hgnc/4620 -->

    <Class rdf:about="http://identifiers.org/hgnc/4620">
        <rdfs:label>GSN</rdfs:label>
    </Class>
    


    <!-- http://identifiers.org/hgnc/8803 -->

    <Class rdf:about="http://identifiers.org/hgnc/8803">
        <rdfs:label>PDGFRA</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000000 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000000">
        <rdfs:label>cell</rdfs:label>
        <rdfs:label xml:lang="en">cell type (from CL)</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_4030032 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_4030032">
        <rdfs:label>valve interstitial cell</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000000"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000946"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0015004"/>
                <someValuesFrom>
                    <Class>
                        <intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/SO_0001260"/>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/4620"/>
                            </Restriction>
                            <Restriction>
                                <onProperty rdf:resource="http://purl.org/ccf/has_marker_component"/>
                                <someValuesFrom rdf:resource="http://identifiers.org/hgnc/8803"/>
                            </Restriction>
                        </intersectionOf>
                    </Class>
                </someValuesFrom>
            </Restriction>
        </rdfs:subClassOf>
        <dcterms:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-12-06T14:18:45Z</dcterms:date>
        <rdfs:comment>Activated valve interstitial cells undergo continual turn over into deactivated fibroblasts and other cell fates (such as apoptosis).</rdfs:comment>
        <oboInOwl:id>CL:4030032</oboInOwl:id>
        <skos:prefLabel>valve interstitial cell</skos:prefLabel>
        <ns6:ccf_asctb_type>CT</ns6:ccf_asctb_type>
        <ns6:ccf_pref_label>valve interstitial cell</ns6:ccf_pref_label>
        <oboInOwl:hasExactSynonym>cardiac valve interstitial cell</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>VIC</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>valvular interstitial cell</oboInOwl:hasExactSynonym>
        <ns5:IAO_0000115>An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes.</ns5:IAO_0000115>
        <ns6:ccf_ct_isa rdf:resource="http://purl.obolibrary.org/obo/CL_0000000"/>
        <ns5:RO_0002175 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
        <ns6:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000946"/>
        <ns6:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000948"/>
        <ns6:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002134"/>
        <ns6:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002135"/>
        <ns6:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002137"/>
        <ns6:ccf_located_in rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002146"/>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/cl.owl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas"/>
        <dcterms:contributor rdf:resource="https://orcid.org/0000-0002-1773-2692"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_9606 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9606">
        <rdfs:label>Homo sapiens</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/SO_0001260 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/SO_0001260">
        <rdfs:label>sequence collection</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000946 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000946">
        <rdfs:label>cardiac valve</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000948 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000948">
        <rdfs:label>heart</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0002134 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0002134">
        <rdfs:label>tricuspid valve</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0002135 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0002135">
        <rdfs:label>mitral valve</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0002137 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0002137">
        <rdfs:label>aortic valve</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0002146 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0002146">
        <rdfs:label>pulmonary valve</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



