human_reference_atlas part of Homo sapiens organ part red pulp of spleen splenic cord splenic cord AS UMLS:C0735011 MA:0002671 UBERON:0001266 FMA:16031 uberon Splenic Cord Wikipedia:Cords_of_Billroth NCIT:C33599 cord of Billroth A structure found in the red pulp of the spleen between the sinusoids, consisting of fibrils and connective tissue cells with a large population of monocytes and macrophages. These cords contain half of the human body's monocytes as a reserve so that after tissue injury these monocytes can move in and aid locally sourced monocytes in wound healing. Erythrocytes pass through the cords of Billroth before entering the sinusoids. The passage into the sinusoids may be seen as a bottleneck, where erythrocytes need to be flexible in order to pass through. In disorders of erythrocyte shape and/or flexibility, such as hereditary spherocytosis, erythrocytes fail to pass through and get phagocytosed, causing extravascular hemolysis. EMAPA:37752 cord of Bilroth