sphingosine-1-phosphate signaling pathway Reactome:REACT_18416.2 S1P-activated GPCR signaling pathway dph A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. GO:0003376 S1P signaling pathway S1P receptor signaling pathway S1P-activated G-protein coupled receptor signaling pathway 2009-12-09T06:30:12Z Sphingosine-1-phosphate (S1P) can act both as an extracellular ligand for cell surface G-protein coupled receptors, and as an intracellular second messenger. GO:0003376 describes a pathway where S1P acts as an extracellular ligand. Where S1P acts within the cell to transmit a signal, consider instead 'intracellular signal transduction ; GO:0035556' or 'G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) ; GO:0001789'. sphingolipid signalling pathway S1P-stimulated signal transduction pathway biological_process sphingolipid signaling pathway G-protein coupled receptor signaling pathway sphingolipid mediated signaling pathway