exo-alpha-sialidase activity acetylneuraminyl hydrolase activity Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. MetaCyc:3.2.1.18-RXN alpha-neuraminidase activity sialidase activity acetylneuraminidase activity N-acylneuraminate glycohydrolase activity GO:0004308 EC:3.2.1.18 Reactome:REACT_6348 Reactome:REACT_116118 Reactome:REACT_115699 neuraminidase activity molecular_function Reactome:REACT_115906 alpha-sialidase activity