part_of phosphoprotein phosphatase activity protein tyrosine phosphatase activity molecular_function EC:3.1.3.48 Reactome:REACT_24939 Reactome:REACT_91510 GO:0004725 phosphotyrosine protein phosphatase activity Reactome:REACT_98860 Reactome:REACT_34493 Reactome:REACT_111128 PPT-phosphatase activity Reactome:REACT_25190 Reactome:REACT_111048 Reactome:REACT_12446 Reactome:REACT_105172 Reactome:REACT_25311 Reactome:REACT_109643 Reactome:REACT_79081 Reactome:REACT_95709 Reactome:REACT_113070 protein phosphotyrosine phosphatase activity Reactome:REACT_18389 PTPase activity Reactome:REACT_108914 Reactome:REACT_77215 Reactome:REACT_23816 MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN protein-tyrosine-phosphate phosphohydrolase activity Reactome:REACT_88819 phosphotyrosine histone phosphatase activity Reactome:REACT_25289 Reactome:REACT_83292 Reactome:REACT_90186 Reactome:REACT_82080 Reactome:REACT_25329 Reactome:REACT_92520 Reactome:REACT_97978 Reactome:REACT_115220 Reactome:REACT_112153 Reactome:REACT_93431 [phosphotyrosine]protein phosphatase activity Reactome:REACT_111061 Reactome:REACT_115381 phosphoprotein phosphatase (phosphotyrosine) activity Reactome:REACT_1810 Reactome:REACT_86824 Reactome:REACT_1411 PTP-phosphatase activity tyrosylprotein phosphatase activity phosphotyrosylprotein phosphatase activity Reactome:REACT_101149 Reactome:REACT_22109 Reactome:REACT_107803 tyrosine O-phosphate phosphatase activity Reactome:REACT_92699 phosphotyrosine phosphatase activity Reactome:REACT_112085 Reactome:REACT_111193 Reactome:REACT_91327 Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. Reactome:REACT_453 Reactome:REACT_81528 Reactome:REACT_111038 Reactome:REACT_114866 Reactome:REACT_111157 Reactome:REACT_12439 Reactome:REACT_32566 Reactome:REACT_28210 Reactome:REACT_25185 protein-tyrosine-phosphatase activity Reactome:REACT_18414 Reactome:REACT_15464 Reactome:REACT_100540 Reactome:REACT_19146 Reactome:REACT_104864 Reactome:REACT_97438 Reactome:REACT_93753 Reactome:REACT_103930 peptidyl-tyrosine dephosphorylation