thymidylate synthase activity Reactome:REACT_94977 KEGG:R02101 dTMP synthase activity Reactome:REACT_83275 GO:0004799 Reactome:REACT_93781 Reactome:REACT_106949 Reactome:REACT_95603 Reactome:REACT_105743 RHEA:12107 EC:2.1.1.45 Reactome:REACT_96474 Reactome:REACT_108055 Reactome:REACT_34727 Reactome:REACT_1679 Reactome:REACT_80685 Reactome:REACT_82204 Reactome:REACT_86925 TMP synthetase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. molecular_function Reactome:REACT_90103 Reactome:REACT_95751 Reactome:REACT_97834 Reactome:REACT_78293 MetaCyc:THYMIDYLATESYN-RXN 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity Reactome:REACT_96780 methylenetetrahydrofolate:dUMP C-methyltransferase activity thymidylate synthetase activity Reactome:REACT_108220 5,10-methylenetetrahydrofolate-dependent methyltransferase activity