part_of sequence-specific DNA binding RNA polymerase II transcription factor activity ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'. ligand-dependent nuclear receptor activity nuclear hormone receptor GO:0004879 nuclear receptor activity ligand-dependent transcription factor activity Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. molecular_function intracellular receptor signaling pathway direct ligand regulated sequence-specific DNA binding transcription factor activity