apoptotic process apoptotic cell death Reactome:REACT_90267 Reactome:REACT_79809 Reactome:REACT_28816 Reactome:REACT_31349 Reactome:REACT_111964 Reactome:REACT_99799 Reactome:REACT_95675 type I programmed cell death commitment to apoptosis Reactome:REACT_101249 Reactome:REACT_110081 Reactome:REACT_34139 apoptotic programmed cell death Reactome:REACT_30371 Reactome:REACT_77415 Reactome:REACT_97627 Reactome:REACT_30763 Reactome:REACT_87570 GO:0006915 GO:0006917 Reactome:REACT_91243 signaling (initiator) caspase activity Reactome:REACT_89196 programmed cell death by apoptosis Reactome:REACT_85877 Reactome:REACT_106672 Reactome:REACT_100045 cellular suicide Reactome:REACT_108651 Reactome:REACT_88784 Reactome:REACT_88740 Reactome:REACT_82724 Reactome:REACT_100962 Reactome:REACT_77132 Reactome:REACT_93937 Reactome:REACT_28087 Reactome:REACT_30361 cell suicide activation of apoptosis Reactome:REACT_91011 Reactome:REACT_105149 Reactome:REACT_104187 apoptosis activator activity Reactome:REACT_83328 Reactome:REACT_28795 induction of apoptosis Reactome:REACT_13638 apoptotic program Reactome:REACT_86873 induction of apoptosis by p53 Reactome:REACT_30266 Reactome:REACT_78802 Reactome:REACT_77313 GO:0008632 Reactome:REACT_99784 Reactome:REACT_94099 Reactome:REACT_106405 Reactome:REACT_30548 A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase, and an execution phase, which is triggered by the former. Reactome:REACT_578 Reactome:REACT_95069 apoptosis signaling biological_process Reactome:REACT_107264 Reactome:REACT_86749 Reactome:REACT_109165 Wikipedia:Apoptosis Reactome:REACT_13526 Reactome:REACT_78287 Reactome:REACT_13643 apoptosis programmed cell death