abnormal innate immunity abnormal leukocyte physiology abnormal macrophage physiology MP:0002451 MPheno.ontology any functional anomaly of the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells macrophage dysfunction abnormal professional antigen presenting cell physiology