altered response to CNS ischemic injury increased susceptibility to ischemic brain injury MPheno.ontology increased frequency or more severe response, such as necrotic tissue size, to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of all or part of the brain tissue, compared to controls increased CNS stroke decreased resistance to ischemic brain injury increased susceptibility to spontaneous CNS ischemia MP:0006081 MP:0003076 increased susceptibility to injury