altered response to CNS ischemic injury increased susceptibility to ischemic brain injury MP:0003076 MP:0006081 MPheno.ontology decreased resistance to ischemic brain injury increased CNS stroke increased frequency or more severe response, such as necrotic tissue size, to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of all or part of the brain tissue, compared to controls increased susceptibility to spontaneous CNS ischemia increased susceptibility to injury