increased susceptibility to infection increased susceptibility to prion infection MP:0003004 MP:0005364 MPheno.ontology decreased resistance to prion infection increased likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component susceptibility to prion infection altered susceptibility to prion infection