decreased Langerhans cell number reduced number of Langerhans cells reduced Langerhans cell number decreased number of Langerhans cells MPheno.ontology reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus MP:0008119 decreased myeloid dendritic cell number abnormal Langerhans cell number