abnormal mitochondrial physiology abnormal aerobic respiration abnormal tricarboxylic acid cycle 2011-03-24T11:23:08Z GO:0006099 In eukaryotes the tricarboxylic acid is confined to the mitochondria. MP:0010958 MPheno.ontology abnormal Krebs cycle abnormal TCA cycle abnormal citric acid cycle any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle csmith