abnormal limb bud morphology abnormal limb mesenchyme morphology any structural anomaly in the primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells MPheno.ontology MP:0011261 2011-09-13T11:41:26Z abnormal limb bud mesenchyme csmith