abnormal optic fissure closure delayed optic fissure closure 2014-01-01T22:14:46Z MP:0012536 MPheno.ontology csmith delayed choroid fissure closure delayed choroidal fissure closure delayed embryonic fissure closure delayed fetal fissure closure delayed retinal fissure closure late onset of the initiation and/or completion of closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk