decreased neural crest cell number abnormal cardiac neural crest cell morphology decreased cardiac neural crest cell number 2014-03-27T16:25:55Z MP:0012749 MPheno.ontology csmith decreased cardiac NCC number reduced cardiac NCC number reduced cardiac neural crest cell number reduction in the number of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT), and contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia