decreased neural crest cell number abnormal enteric neural crest cell morphology decreased enteric neural crest cell number 2014-05-06T00:00:00Z MP:0013002 MPheno.ontology a reduction in the number of neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut csmith decreased ENCC number decreased ENCDC number decreased enteric neural crest-derived cell number reduced ENCC number reduced ENCDC number reduced enteric neural crest cell number reduced enteric neural crest-derived cell number