two-dimensional liquid chromatography-tandem mass spectrometry strong-cation-exchange reversed-phase high-performance liquid chromatography inductively coupled plasma mass spectrometry A method where the sample is first subjected to two-dimensional high-performance liquid chromatography (passed through two columns in sequence –-a primary ion-exchange column where the particles show no loss or gain of charge with varying pH, and a secondary column where the stationary phase is significantly less polar than the mobile phase). The eluent is then subjected to mass spectrometry where it is ionised in a plasma (a partially ionised gas–-such as Ar–-containing free electrons) which has been generated by electromagnetic induction. https://orcid.org/0000-0001-5985-7429 2009-06-19T11:44:18Z SCX-RP HPLC-ICP-MS CHMO:0002000