multiple isomorphous replacement multiple isomorphous replacement with anomalous scattering 2010-07-26T11:12:12Z MIRAS CHMO:0002727 A method for providing phasing necessary for X-ray crystallography information by growing a number of crystals of the sample substituted with different heavy metal atoms and analysing the X-ray data for each crystal. When the absorption edge of an atom in the crystals is close to the wavelength of the incident radiation the atom becomes an anomalous scatterer. Anomalous scattering can be used for phase determination and also for determining the absolute configuration. Hils FIX:0000247