chemical inhibits protein chemical inhibits in vitro invasion of virus capable of inhibiting activity of has role has role has functional parent is conjugate base of 4-guanidinobenzoic acid camostat chebi_ontology camostat C20H22N4O5 Chemspider:2440 PMID:33505639 N,N-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate PMID:26166259 A benzoate ester resulting from the formal condensation of the carboxy group of 4-guanidinobenzoic acid with the hydroxy group of 2-(dimethylamino)-2-oxoethyl (4-hydroxyphenyl)acetate. It is a potent inhibitor of the human transmembrane protease serine 2 (TMPRSS2) and its mesylate salt is currently under investigation for its effectiveness in COVID-19 patients. KEGG:D07606 4-{2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate Drug_Central:471 PMID:33564221 PMID:33676899 CHEBI:135632 398.419 PMID:33225308 https://www.drugbank.ca/drugs/DB13729 Reference: PMID: 22496216 398.15902 PMID:23412700 PMCID:PMC7809394 camostatum CAS:59721-28-7 0 PMID: 28855003; PMID: 25666761 PMID:7341342 CN(C)C(=O)COC(=O)CC1=CC=C(OC(=O)C2=CC=C(NC(N)=N)C=C2)C=C1 XASIMHXSUQUHLV-UHFFFAOYSA-N DrugBank:DB13729 InChI=1S/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23) Wikipedia:Camostat PMID: 32142651 PMID:26887332 4-{2-[(dimethylcarbamoyl)methoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate PMID:33176395 tertiary carboxamide anticoronaviral agent camostat(1+) antiviral agent guanidines carboxylic ester inhibitor antineoplastic agent antihypertensive agent benzoate ester antifibrinolytic drug diester serine protease inhibitor anti-inflammatory agent Middle East respiratory syndrome-related coronavirus SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus transmembrane protease serine 2 (human) serine protease 1 (human)